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The unixODBC driver creates a linking failure in PHP if any extension using the old SQL-CLI (libdb400.a) driver is also loaded.  This is because there is a naming conflict between the drivers that will cause the linked SQLSetEnvAttrr to be called from the wrong driver, and PHP will fail to start. So, before you can enable the PDO_ODBC extension, you need to disable the odbc, pdo_ibm, and ibm_db2 extensions.  (You need to disable the odbc extension because it uses SQL-CLI instead of unixODBC.  This was done to maintain backward compatibility with older versions of Zend Server). 

This will happen automatically in Zend Server.  If you enable PDO_ODBC, the others will be disabled.  If you enable any of the others, PDO_ODBC will be disabled.  It is important to understand that you can not run scripts using incompatible DB2 drivers at the same time.  For example, if you migrate some of your ibm_db2 applications to PDO_ODBC, you must migrate all of your ibm_db2 applications to PDO_ODBC.